Interleukin-10 and Interleukin-1 receptor antagonists increase during cardiac surgery

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Interleukin-10 and interleukin-1 receptor antagonists increase during cardiac surgery.

BACKGROUND It has been reported that inflammatory cytokines such as interleukin-8 and 6 (IL-8, IL-6) increase during cardiac surgery and caused postoperative cardiac dysfunction. Therefore, it is important to investigate changes of suppressive cytokines such as IL-10, interleukin-4 (IL-4) and interleukin-1 receptor antagonist (IL-1ra) during cardiac surgery. METHOD Serum levels of cytokines a...

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Interleukin Antagonists

There is strong experimental and clinical support for a causal role of immune dysregulation and inflammation in atherosclerosis and heart failure. Atherosclerotic lesions are infiltrated by monocytes, macrophages, and T lymphocytes (predominantly Th1). Cytokines, including interleukin-6 (IL6) and tumor necrosis factor-α (TNF-α), are released by the infiltrating inflammatory cells and stimulate ...

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Interleukin-1 antagonists in Mevalonate Kinase Deficiency

Background Mevalonate Kinase Deficiency (MKD) is one of the autoinflammatory fever syndromes, caused by mutations in the MKD gene. Systemic inflammatory symptoms may be mild to severe leading to early death, and recurrent bacterial infections frequently develop in the disease course. On demand NSAID and steroids are the most commonly used. Few case-reports suggested that interleukin-1 (IL-1) an...

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ژورنال

عنوان ژورنال: Canadian Journal of Anaesthesia

سال: 1997

ISSN: 0832-610X,1496-8975

DOI: 10.1007/bf03014322